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Atovaquone

Atovaquone (alternative spelling: atavaquone) is a chemical compound that belongs to the class of naphthoquinones. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. It is manufactured in the US in the liquid form, or oral suspension, under the brand name Mepron.

Uses

Atovaquone is a medication used to treat or prevent:
  1. For pneumocystis pneumonia (PCP), it is used in mild cases, although it is not approved for treatment of severe cases.
  2. For toxoplasmosis, the medication has antiparasitic and therapeutic effects.
  3. For malaria, it is one of the two components (along with proguanil) in the drug Malarone. Malarone has fewer side effects and is more expensive than mefloquine. Malarone: New Malaria Medication With Fewer Side-effects Resistance has been observed.
  4. For babesia, it is often used in conjunction with oral azithromycin.{{cite journal
| vauthors=Krause PJ, Lepore T, Sikand VK |title=Atovaquone and azithromycin for the treatment of babesiosis |journal=N. Engl. J. Med. |volume=343 |issue=20 |pages=1454–8 |date=November 2000 |pmid=11078770 |url=http://content.nejm.org/cgi/content/full/343/20/1454 | doi=10.1056/NEJM200011163432004 | display-authors=etal}} Trimethoprim/sulfamethoxazole (TMP-SMX, Bactrim) is generally considered first-line therapy for PCP or toxoplasmosis. However, atovaquone may be used in patients who cannot tolerate, or are allergic to, sulfonamide medications such as TMP-SMX. In addition, atovaquone has the advantage of not causing myelosuppression, which is an important issue in patients who have undergone bone marrow transplantation.

Malaria

Atovaquone, as a combination preparation with proguanil, has been commercially available from GlaxoSmithKline since 2000 as Malarone for the treatment and prevention of malaria.

References

External links

"green air" © 2007 - Ingo Malchow, Webdesign Neustrelitz
This article based upon the http://en.wikipedia.org/wiki/Atovaquone, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Atovaquone&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany