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Butylated hydroxyanisole

| Section2 = {{Chembox Properties | C=11|H=16|O=2 | Appearance = waxy solid | Density = 1.0587 g/cm3 at 20 °C | MeltingPtC = 48 to 55 | BoilingPtC = 264 to 270 | Solubility = Insoluble in water | SolubleOther = freely soluble in ethanol, methanol, propylene glycol; soluble in fats and oils | RefractIndex = 1.5303 at 589.3nm }} | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} | Section4 = {{Chembox Related | OtherCompounds = Butylated hydroxytoluene }} }} Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. It is prepared from 4-methoxyphenol and isobutylene. It is a waxy solid used as a food additive with the E number E320. The primary use for BHA is as an antioxidant and preservative in food, food packaging, animal feed, cosmetics, rubber, and petroleum products. Hazardous Substances Database, National Library of Medicine BHA also is commonly used in medicines, such as isotretinoin, lovastatin, and simvastatin, among others.

Antioxidant properties

Since 1947, BHA has been added to edible fats and fat-containing foods for its antioxidant properties as it prevents rancidification of food which creates objectionable odors. Like butylated hydroxytoluene (BHT), the conjugated aromatic ring of BHA is able to stabilize free radicals, sequestering them. By acting as free radical scavengers, further free radical reactions are prevented.


The U.S. National Institutes of Health report that BHA is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. In particular, when administered in high doses as part of their diet, BHA causes papillomas and squamous cell carcinomas of the forestomach in rats and Syrian golden hamsters. Butylated Hydroxyanisole (BHA), CAS No. 25013-16-5, Report on Carcinogens, Eleventh Edition, National Institutes of Health In mice, there is no carcinogenic effect, and even evidence of a protective effect against the carcinogenicity of other chemicals. When examining human population statistics, the usual low intake levels of BHA show no significant association with an increased risk of cancer. The State of California, has, however, listed it as a carcinogen.

See also


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This article based upon the http://en.wikipedia.org/wiki/Butylated_hydroxyanisole, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Butylated_hydroxyanisole&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany