s to form a peptide bond (red) with expulsion of water (blue)]] A condensation reaction is a chemical reaction in which two molecules or moieties, often functional groups, combine to form a larger molecule, together with the loss of a small molecule. Possible small molecules that are lost include water, acetic acid, hydrogen chloride, or methanol, but most commonly in biological reactions it is water. Condensations producing water as a byproduct are the opposite reaction of transformations involving hydrolysis, which split a reactant into two new species through addition of a water molecule. Condensation can be intermolecular (between two different molecules) or intramolecular (involving different groups within the same molecule). A simple example of an intermolecular condensation is the joining of two amino acids in the peptide bond, as is characteristic of all proteins. Examples of intramolecular condensations often lead to ring formation, and include the synthesis of cyclic peptides via the same bond forming process as just described, as well as Dieckmann condensations, in which the two ester groups within a diester molecule react with release of an alcohol molecule to form a β- ketoester product.Actually in this process two water molecules are released. As given below (n+n=2n) The condensation reaction-speed can be catalyzed, by simply adding a concentrated acid to the reaction. It effects it by acidifying the environment whereas the reaction takes place the acid thereby binds with the water molecules and speed up the process.
MechanismsCondensation reactions can follow a variety of different reaction mechanisms, depending on the groups reacting and the conditions employed to perform the reaction (solvent, temperature, reaction additives, etc.).
ApplicationsMany artificial, man-made chemical reactions, and many biological transformations are condensation reactions. In the latter case (reactions in nature), phosphorylation and glycosylation reactions are generally all condensations, as are the key bond-forming reactions in all polypeptide and polynucleotide syntheses, and much of polyketide and terpene biosynthesis as well. Examples of the large number of condensation reactions are used in synthetic organic chemistry include:
- Acyloin condensation
- Aldol condensation
- Claisen condensation
- Claisen–Schmidt condensation
- Darzens reaction (glycidic ester condensation)
- Dieckmann condensation
- Guareschi–Thorpe condensation
- Knoevenagel condensation
- Pechmann condensation
- Rap–Stoermer condensation
- Self-condensation or symmetrical aldol condensation
- Thorpe–Ziegler reaction