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The diplomonads (Greek for "two units") are a group of flagellates, most of which are parasitic. They include Giardia lamblia, which causes giardiasis in humans. They are placed among the metamonads, and appear to be particularly close relatives of the retortamonads. Most diplomonads are double cells: they have two nuclei, each with four associated flagella, arranged symmetrically about the body's main axis. Like the retortamonads, they lack both mitochondria and Golgi apparatuses. However, they are now known to possess modified mitochondria, in the case of G. lamblia, called mitosomes. These are not used in ATP synthesis the way mitochondria are, but are involved in the maturation of iron-sulfur proteins.

Possible sexual reproduction in Giardia

The common intestinal parasite Giardia intestinalis (synonyms Giardia lamblia, G. duodenalis) was once considered to be a descendant of a protist lineage that predated the emergence of meiosis and sex. However, G. intestinalis has now been found to have a core set of genes that function in meiosis and that are widely present among sexual eukaryotes. These results suggested that G. intestinalis is capable of meiosis and thus sexual reproduction. Furthermore, Cooper et al. found direct evidence in G. intestinalis for infrequent meiotic recombination, indicative of sexual reproduction between individuals. Lasek-Nesselquist et al. also detected molecular signatures consistent with meiotic sex. G. intestinalis contains two functionally equivalent nuclei that are inherited independently during mitosis. In the giardial cyst these nuclei fuse ( karyogamy) and undergo homologous recombination facilitated by meiosis gene homologs. The recombination associated with karyogamy may primarily function to repair DNA damage. G. intestinales is divided into eight assemblages based on host specificities and genetic divergence of marker genes. Although recombination can occur infrequently within assemblages, Xu et al. found that recombination between individuals from different assemblages is very rare. They suggested that the assemblages are genetically isolated lineages, and thus could be viewed as separated Giardia species.


External links

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This article based upon the http://en.wikipedia.org/wiki/Diplomonad, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Diplomonad&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany