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Karl August Folkers

Karl August Folkers (September 1, 1906 – December 7, 1997) was an American biochemist who made major contributions to the isolation and identification of bioactive natural products.{{cite journal |last=Shive |first=William |authorlink= |year=2002 |month= |title=Karl August Folkers, September 1, 1906 – December 9, 1997 |journal=Biographical memoirs. National Academy of Sciences (U.S.) |volume=81 |issue= |pages=100–14 | publisher = | location = | pmid = 12661556 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}{{cite journal |last=Olson |first=R E |authorlink= |title=Karl August Folkers (1906–1997) |journal=Journal of Nutrition |volume=131 |issue=9 |pages=2227–30 | publisher = | location = | pmid = 11533258 | bibcode = | oclc =| id = | url = http://jn.nutrition.org/cgi/content/full/131/9/2227 | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | date = September 1, 2001 }}

Career

His career was mainly spent at Merck. He played a prominent role in the isolation of vitamin B12, which is one of the most structural complex of the vitamins. As a Merck Pharmaceuticals research team, Folkers, Fern P. Rathe, and Edward Anthony Kaczka were the first to isolate the antibiotic cathomycin in 1955.Acc. 90-105 - Science Service, Records, 1920s-1970s, Smithsonian Institution Archives. Accessed 29 July 2013. http://siarchives.si.edu/collections/siris_arc_297416 His team also isolated the antibiotic cycloserine.Kuehl, Frederick A., Jr.; Wolf, Frank J.; Trenner, Nelson R.; Peck, Robert L.; Buhs, Rudolf P.; Putter, Irvin; Ormond, Robert; Lyons, John E.; Chaiet, Louis; Howe, Eugene; Hunnewell, Berl D.; Downing, Geo.; Newstead, E.; Folkers, Karl "D-4-Amino-3-isoxazolidinone, a new antibiotic" Journal of the American Chemical Society 1955, vol. 77, pp. 2344-5. . Stammer, Charles H.; Wilson, Andrew N.; Holly, Frederick W.; Folkers, Karl "Synthesis of D-4-amino-3-isoxazolidinone" Journal of the American Chemical Society 1955, volume 77, 2346-7. In 1958 his Merck team determined the structure of coenzyme Q10. History of CoQ10 In recognition for his scientific contributions, he received the Perkin Medal in 1960, the Priestley Medal in 1986, and the National Medal of Science in 1990.

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External links

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