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Lanosterol

|Section2={{Chembox Properties | Formula = C30H50O | MolarMass = 426.71 g/mol | Appearance = | Density = | MeltingPtC = 138 to 140 | MeltingPt_notes = | BoilingPt = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast plant steroids are produced via cycloartenol.

Role in creation of steroids

Elaboration of lanosterol under enzyme catalysis leads to the core structure of steroids. 14-Demethylation of lanosterol by CYP51 eventually yields cholesterol.

Biosynthesis

Clinical significance

Preliminary studies in dogs and rabbits have shown that lanosterol can prevent and even reverse cataract formation.Groß, M. (2015), Aggregate aufgelöst. Chemie in unserer Zeit. However, an attempt to replicate these results in age-related cataractous human lens nuclei removed during manual small incision cataract surgery by immersing them in lanosterol solution and incubating them for 6 days according to the method of Zhao et al., failed to reverse nuclear opacity.Shanmugam, P. M., Barigali, A., Kadaskar, J., Borgohain, S., Mishra, D. K. C., Ramanjulu, R., & Minija, C. K. (2015). Effect of lanosterol on human cataract nucleus. Indian journal of ophthalmology, 63(12), 888-890

See also

References

  • {{cite journal
| author = E. J. Corey, W. E. Russey, P. R. Ortiz de Montellano | title = 2,3-Oxidosqualene, an Intermediate in the Biological Synthesis of Sterols from Squalene | journal = Journal of the American Chemical Society | volume = 88 | issue = 20 | year = 1966 | pages = 4750–4751 | doi = 10.1021/ja00972a056 | pmid =5918046}}
  • {{cite journal
|author1=I. Abe |author2=M. Rohmer |author3=G. D. Prestwich | title = Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes | journal = Chemical Reviews | volume = 93 | issue = 6 | year = 1993 | pages = 2189–2206 | doi = 10.1021/cr00022a009}}
  • {{cite journal
| author = A. Eschenmoser, L. Ruzicka, O. Jeger, D. Arigoni | title = Zur Kenntnis der Triterpene. 190. Mitteilung. Eine stereochemische Interpretation der biogenetischen Isoprenregel bei den Triterpenen | journal = Helvetica Chimica Acta | volume = 38 | issue = 7 | year = 1955 | pages = 1890–1904 | doi = 10.1002/hlca.19550380728}}

External links

"green air" © 2007 - Ingo Malchow, Webdesign Neustrelitz
This article based upon the http://en.wikipedia.org/wiki/Lanosterol, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Lanosterol&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany