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Mitochondrial myopathy

Mitochondrial myopathies are types of myopathies associated with mitochondrial disease. National Institute of Neurological Disorders and Stroke|website=www.ninds.nih.gov|access-date=2017-02-28}} On biopsy, the muscle tissue of patients with these diseases usually demonstrate "ragged red" muscle fibers. These ragged-red fibers contain mild accumulations of glycogen and neutral lipids, and may show an increased reactivity for succinate dehydrogenase and a decreased reactivity for cytochrome c oxidase. Inheritance was believed to be maternal ( non-Mendelian extranuclear). It is now known that certain nuclear DNA deletions can also cause mitochondrial myopathy such as the OPA1 gene deletion. There are several subcategories of mitochondrial myopathies.

Signs and symptoms

Signs and symptoms include (for each of the following causes):

Cause

Diagnosis

Gomori thrichrome stain: ragged red fibers

Treatment

Although no cure currently exists, there is hope in treatment for this class of hereditary diseases with the use of an embryonic mitochondrial transplant.

References

External links

"green air" © 2007 - Ingo Malchow, Webdesign Neustrelitz
This article based upon the http://en.wikipedia.org/wiki/Mitochondrial_myopathy, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Mitochondrial_myopathy&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany