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Octyl methoxycinnamate

|Section2={{Chembox Properties | C=18 | H=26 | O=3 | Appearance= | Density=1.01 g/cm3 | MeltingPtC = -25 | BoilingPtC=198 to 200 | Solubility= }} |Section6={{Chembox Pharmacology | ATCCode_prefix = D02 | ATCCode_suffix = BA02 }} |Section7={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = | NFPA-H= 1 | NFPA-F= 1 | NFPA-R= 0 }} }} Octyl methoxycinnamate or ethylhexyl methoxycinnamate ( INCI) or octinoxate ( USAN), trade names Eusolex 2292 and Uvinul MC80, is an organic compound that is an ingredient in some sunscreens and lip balms. It is an ester formed from methoxycinnamic acid and (RS)-2-ethylhexanol. It is a clear liquid that is insoluble in water. Its primary use is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage. It is also used to reduce the appearance of scars.

Uses

Often used as an active ingredient in sunscreens combined with oxybenzone and titanium oxide for its use in protection against UV-B rays.

Safety studies

One study performed in 2000 raised safety concerns about octyl methoxycinnamate by demonstrating toxicity to mouse cells at concentrations lower than typical levels in sunscreens. Sinister side of sunscreens, Rob Edwards, New Scientist, 7 October 2000 |title=Toxicity and Phototoxicity of Chemical Sun Filters |journal=Radiation Protection Dosimetry |volume=91 |pages=283–6 |year=2000 |last1=Butt |first1=S.T. |last2=Christensen |first2=T. }} However, another study concluded that octyl methoxycinnamate and other sun screening agents do not penetrate the outer skin in sufficient concentration to cause any significant toxicity to the underlying human keratinocytes. Estrogenic and neurological effects were noted in laboratory animals at concentrations close to those experienced by sunscreen users and were also shown in vitro. Octyl methoxycinnamate has been shown to be light sensitive with a decrease in UV absorption efficiency upon light exposure. This degradation causes formation of the Z-octyl-p-methoxycinnamate from the E-octyl-p-methoxycinnamate. In contrast, the OMC does not show degradation when kept in darkness for extended periods of time. A study carried out in 2017 by the Research Centre for Toxic Compounds in the Environment at Masaryk University, Czech Republic, indicates that octyl methoxycinnamate (EHMC) may damage human cell DNA. When exposed to sun rays, the spatial arrangement of its molecules changes and isomerisation takes place. While until now only unchanged EHMC has been researched, Massaryk University researchers focused on its isomers and found out that it has a significant genotoxic effect under lab conditions. It means that it may potentially damage human DNA and cause genome mutations which may lead to serious health risks.

See also

References

"green air" © 2007 - Ingo Malchow, Webdesign Neustrelitz
This article based upon the http://en.wikipedia.org/wiki/Octyl_methoxycinnamate, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Octyl_methoxycinnamate&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany