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Pyrroloquinoline quinone

|Section2={{Chembox Properties | C=14 | H=6 | N=2 | O=8 | Appearance= | Density=1.963 g/cm3 | MeltingPt= | BoilingPt= | Solubility= }} |Section3={{Chembox Hazards | MainHazards= | FlashPtC = 569.8 | AutoignitionPtC = }} }} Pyrroloquinoline quinone (PQQ) is redox cofactor. It is found in soil and foods such as kiwifruit, as well as human breast milk. Enzymes containing PQQ are called quinoproteins. Glucose dehydrogenase, one of the quinoproteins, is used as a glucose sensor. PQQ stimulates growth in bacteria.

History

It was discovered by J.G. Hauge as the third redox cofactor after nicotinamide and flavin in bacteria (although he hypothesised that it was naphthoquinone). Anthony and Zatman also found the unknown redox cofactor in alcohol dehydrogenase. In 1979, Salisbury and colleagues as well as Duine and colleagues extracted this prosthetic group from methanol dehydrogenase of methylotrophs and identified its molecular structure. Adachi and colleagues discovered that PQQ was also found in Acetobacter.

Controversy regarding role as vitamin

The scientific journal Nature published the 2003 paper by Kasahara and Kato that essentially stated that PQQ was a new vitamin and in 2005, an article by Anthony and Fenton that stated that the 2003 Kasahara and Kato paper drew incorrect and unsubstantiated conclusions.{{cite journal |vauthors=Felton LM, Anthony C | title = Biochemistry: role of PQQ as a mammalian enzyme cofactor? | journal = Nature| year = 2005| pmid = 15689995 | doi=10.1038/nature03322 | volume=433 | issue=7025 | pages=E10; discussion E11–2 }}

See also

L-aminoadipate-semialdehyde dehydrogenase. It was reported that aminoadipate semialdehyde dehydrogenase (AASDH) might also use PQQ as a cofactor, suggesting a possibility that PQQ is a vitamin in mammals. .}}

References

"green air" © 2007 - Ingo Malchow, Webdesign Neustrelitz
This article based upon the http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Pyrroloquinoline_quinone&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany