On Air

Investment

Buy this Domain?
Do you interesting about this domain and the running project?
Feel free to send your offer to webmaster.
pay with Paypal

Advertising

Serum iron

Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells. About 4% is bound up in myoglobin molecules. Around 30% of the iron in the body is stored as ferritin or hemosiderin in the spleen, the bone marrow and the liver. Small amounts of iron can be found in other molecules in cells throughout the body. None of this iron is directly accessible by testing the serum. However, some iron is circulating in the serum. Transferrin is a molecule produced by the liver that binds one or two iron(III) ions, i.e. ferric iron, Fe3+; transferrin is essential if stored iron is to be moved and used. Most of the time, about 30% of the available sites on the transferrin molecule are filled. The test for serum iron uses blood drawn from veins to measure the iron molecules that are bound to transferrin, and circulating in the blood. The extent to which sites on transferrin molecules are filled by iron ions can be another helpful clinical indicator, known as percent transferrin saturation. Another lab test saturates the sample to measure the total amount of transferrin; this test is called total iron-binding capacity (TIBC). These three tests are generally done at the same time, and taken together are an important part of the diagnostic process for conditions such as anemia, iron deficiency anemia, anemia of chronic disease and Haemochromatosis.

Normal values

Normal reference ranges are:
  • Serum iron: Serum Iron. University of Illinois Medical Center. Accessed July 6, 2006.
  • * Men: 65 to 176 μg/dL
  • * Women: 50 to 170 μg/dL
  • * Newborns: 100 to 250 μg/dL
  • * Children: 50 to 120 μg/dL
  • TIBC: 240–450 μg/dL
  • Transferrin saturation: 20–50%
μg/dL = micrograms per deciliter. Laboratories often use different units and "normal" may vary by population and the lab techniques used; look at the individual laboratory reference values to interpret a specific test (for instance, your own). , comparing blood content of iron and related compounds (shown in brown and orange) with other constituents.]]

See also

References

Further reading

  • Medline Plus Medical Encyclopedia: Serum Iron.
  • Schrier SL. Regulation of iron balance. Up-to-Date. Accessed December 5, 2005. (Requires subscription.)
"green air" © 2007 - Ingo Malchow, Webdesign Neustrelitz
This article based upon the http://en.wikipedia.org/wiki/Serum_iron, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Serum_iron&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany