On Air

Advertising

Tyloxapol

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions,{{Cite journal | last1 = Sehgal | first1 = S. S. | last2 = Ewing | first2 = C. K. | last3 = Richards | first3 = T. | last4 = Taeusch | first4 = H. W. | title = Modified bovine surfactant (Survanta) versus a protein-free surfactant (Exosurf) in the treatment of respiratory distress syndrome in preterm infants: A pilot study | journal = Journal of the National Medical Association | volume = 86 | issue = 1 | pages = 46–52 | year = 1994 | pmid = 8151722 | pmc = 2607653 }}{{Cite journal | doi = 10.1378/chest.101.4.1080 | last1 = Rubin | first1 = B. K. | last2 = Ramirez | first2 = O. | last3 = King | first3 = M. | title = Mucus rheology and transport in neonatal respiratory distress syndrome and the effect of surfactant therapy | journal = Chest | volume = 101 | issue = 4 | pages = 1080–1085 | year = 1992 | pmid = 1555424 }} administered by inhalation through a nebulizerDrugs.com: Tyloxapol definition or with a stream of oxygen. With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals.{{Cite journal | doi = 10.1006/exmp.2002.2449 | last1 = Kourounakis | first1 = A. P. | last2 = Victoratos | first2 = P. | last3 = Peroulis | first3 = N. | last4 = Stefanou | first4 = N. | last5 = Yiangou | first5 = M. | last6 = Hadjipetrou | first6 = L. | last7 = Kourounakis | first7 = P. N. | title = Experimental hyperlipidemia and the effect of NSAIDs | journal = Experimental and molecular pathology | volume = 73 | issue = 2 | pages = 135–138 | year = 2002 | pmid = 12231215 }} Tyloxapol is the main active ingredient of the medical device Tacholiquin®. Tacholiquin® is an expectorant designated for inhalation and instillation reaching the upper and lower airways. Other brand names of pharmaceutical products containing Tyloxpol are Exosurf and Alevaire.

References

"green air" © 2007 - Ingo Malchow, Webdesign Neustrelitz
This article based upon the http://en.wikipedia.org/wiki/Tyloxapol, the free encyclopaedia Wikipedia and is licensed under the GNU Free Documentation License.
Further informations available on the list of authors and history: http://en.wikipedia.org/w/index.php?title=Tyloxapol&action=history
presented by: Ingo Malchow, Mirower Bogen 22, 17235 Neustrelitz, Germany